Trichocereus Pachanoi: Can You Smoke San Pedro Cactus?

Can You Smoke San Pedro Cactus?

We recently tried smoking San Pedro powder. It was a brave thing to do, and we were hoping for a spiritual experience. The results were disheartening.

First, we tried smoking pure harmaline freebase made from Harmine. We dipped a cigarette in the solution and smoked it. Nothing happened at all, except for maybe feeling a little bit high for about one minute (could have been other factors.)

Then we tried smoking San Pedro powder directly. As with the harmaline freebase, nothing happened except for a slight marijuana-like buzz that lasted no more than 30 seconds. 

One point of evidence is that while San Pedro can be bought in its dried form, it is rarely sold in powdered form. Additionally, even with a very fine grind, most smokers report that smoking the powder results in a nasty burning sensation in their mouth and lungs. It would seem clear that smoking san Pedro powder wouldn’t work in the first place.

This is true, but it doesn’t mean that you can’t smoke San Pedro at all. If you want to inhale your San Pedro as opposed to eating or drinking it, you can use the dried cactus itself as an alternative form of smoking material. Just like with your typical cigarette rolling papers, you’ll need to tear off a section of the plant (a length about one inch thick), then break it up into smaller pieces and grind it up into a powder using either a blender or mortar and pestle. Once ground up, you should have something similar to dry tobacco leaf or coffee grounds.

What is the San Pedro cactus?

San Pedro aka Echinopsis pachanoi (basionym: Trichocereus pachanoi) is most well-known from the Trichocereus family. It is a thin cylindrical cactus found in the Andes in South America. It grows quicker than peyote and can grow 30 inches or more an entire year, and often produces huge, white night-blooming flowers.

According to researchers such as Backeberg Trichocereus contains 47 species which are all of which are native in South America. Some say there are only 13 species. Apart from. Pachanoi Some other species contain mescaline too. Mescaline’s amount in a plant depends on the species and the age of the cactus.

Similar to Peyote (and Peruvian torch, among other things), San Pedro contains mescaline, which is one of the best-researched psychedelics on the planet and the first one to use the term. The effects of mescaline are described as empathogenic (similar in some ways to MDMA) and could be life-changing, stimulating radical introspection as well as healing as well as a sense of excitement and wonder.

As a tradition, today San Pedro can be eaten in its own juice or mixed together with other herbs to make the form of a ceremonial concoction referred to as Cimora. Dry San Pedro is estimated to contain as much as 2.375 mescaline per gram However, it also has other alkaloids like hordenine, tyramine, 3-methoxytyr anhalaninine, as well as anhalonidine.

The effects of the San Pedro cactus

Mescaline is a euphoric drug, with effects that range from euphoria to intense, full-blown hallucinations. Today, San Pedro is enjoyed around all over the world as natural psychoactive, indigenous Andean cultures have utilized the cactus to aid in divination purposes. This is why the cactus has been used as a recreational item and also in a spiritual sense to the present.

While the effects of psychoactive substances can be hard to quantify in a precise manner the most common effects observed at San Pedro include the return of forgotten memories intense sensitiveness to light and color and synesthesia. It also alters the perception of time as well as visuals. Closed and open eyes. The latter is of special significance to mescaline users because the chemical can trigger different kinds of visual patterns.

The experience generally is often compared with other hallucinogens due to the spiritual awareness and a sense of connectedness that is prevalent. The effects start about a couple of hours after taking the drug and increase for around 2-4 hours later before dissolving after approximately 8 hours.

The effects of San Pedro are much more pleasing than the effects of peyote. Its peak isn’t as dramatic and isn’t as intense. San Pedro tastes a bit bitter, and typical nausea that is associated with peyote isn’t as typical.

But, San Pedro can still cause nausea and induce vomiting before the journey even begins. It is generally regarded as an act of cleansing which makes sure the body, as well as your mind, are in good health to travel.

There’s no way to know from merely checking the amount of mescaline in a cactus making determining the right dosage quite difficult, particularly considering how diverse San Pedro is. A mere 50g of dried cactus material could contain up to 150mg mescaline (a threshold dose) or even 1150mg mescaline (a potential overdose). Therefore, it is recommended to begin with the lowest dose that is likely to result in negative effects (~7g dried, fresh 107g) and then increase the dose and experiment. But if you only utilize the outer layer the effects are more likely to be more intense.

How is San Pedro used?

While San Pedro has traditionally been utilized for spiritual reasons by certain tribes, it is now well-known worldwide among people who want to relax their minds and heal their past experiences, feel the spirit and the connection to nature, or simply enjoy a San Pedro travel.

It is highly recommended that San Pedro only be taken under the supervision of a skilled animator or shaman. those who are taking it should be closely monitored since the San Pedro experience leads to an altered state of mind lasting for several hours.

Many travelers travel to destinations like Peru, Colombia, or Ecuador where multi-day retreats such as those in San Pedro are offered. They are guided by experienced facilitators who make the infusions and ensure the safety of participants.

Prior to participating in the San Pedro ceremony, participants are usually advised to eat the simplest generally vegetarian, diet for at most one week prior to the event and avoid alcohol, drugs, or sexual activity. This is advised to rid your body of toxins and increase the effect of the ceremony.



  • Mescaline is a drug that induces hallucinations.
  • It is the primary ingredient in peyote, a cactus species used for rituals by Native Americans as well as other species, including San Pedro and Peruvian Torch.
  • It is possible to chew dried parts of plants. or extracted chemically or synthesized in a secret lab.
  • Is it synthetic mescaline, or a derivative of cactus that contains the substance, it is generally taken orally however, it can (rarely) be in a pill.
  • Users can feel the sensation of a “trip” similar to that experienced by LSD and hallucinogenic fungi, which includes hallucinations, distortions of perception as well as a feeling of separation from oneself.
  • People who have had a “bad trip” can experience an unsettling nightmare that lasts for the duration of effects.
  • Mescaline is a relatively scarce street drug because it isn’t financially viable to produce it illegally in huge quantities.
  • It is banned by international law, as per the United Nations Convention on Psychotropic Substances (1971).
  • In the United States, mescaline is classified as a Schedule I drug, just like peyote. However, there are exceptions to allow mescaline’s “non-addictive” ritual use by people belonging to The Native American Church.
  • Regular users can develop an addiction to the drug but in the beginning, there is no chemical dependency.


  • Mescaline first was identified by Western scientists in 1897 and was synthesized for the first time in 1919.
  • An “active dose” of mescaline (strong enough to trigger hallucinations) is believed to range between 200 and 400 mg in the form of this drug. In the case of frequent users of the drug, this amount may be much greater if they’ve developed an addiction.
  • Following consumption of mescaline, the effects can begin to manifest after 30 to 45 mins.
  • The effects may last up to 12 hours or longer.


Is San Pedro cactus poisonous?

Is San Pedro cactus poisonous? Well, as a matter of fact, it is. The San Pedro Cacti are poisonous because they contain mescaline, which can cause hallucinations or delusions if ingested by humans; it also causes nausea when consumed orally with alcohol so be careful!

The mescaline content of the cactus can come in very handy, however. Native populations and ancient civilizations have used the plant for its psychoactive properties, which has been linked to both spiritual and religious experiences. The cactus’ hallucinogenic effects are largely due to the mescaline contained within its stems (the part that’s used) and flowers (which don’t contain any mescaline).

How Long Does Mescaline Stay in Your System?

How long mescaline stays in the system depends on a dizzying number of factors. The type of mescaline ingested, how much was taken, and how long ago it was taken can all affect the length of time that the substance remains detectable in the body. Moreover, because recreational users aren’t typically concerned about keeping track of their drug use, it’s difficult to fully predict how long the effects of mescaline will be felt or how long it will take for the drug to leave your system.

The most common way to test for any kind of drug use is through urine testing, which can detect the presence of a drug as soon as 12 hours after ingestion. However, if someone is taking steps to pass a drug test—for example, drinking lots of water to dilute their urine—the time window for detection could be extended. For most people who are using mescaline recreationally, it won’t be in their bodies for more than three days after use.

Mescaline is detectable by hair follicle testing for up to 60 days after ingestion; however, this method is used primarily by researchers looking to study the effects of mescaline on individuals from various groups in order to test theories about addiction and dependence.


Anwar Hossain

My name is Anwar Hossain. I am a cactus lover, researcher, and cactus blogger.

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